In this study, the Sonata for Flute and Piano, composed by Paul Hindemith; an important German composer, conductor, performer and educator of the 20th century, was examined. Hindemith is the pioneer of Gebrauchsmusik and Neo-Classicism. Composer used flute instrument at his chamber music, opera, symphony works. He composed many works in “Sonata” form. The composer has ten sonatas for wind instruments, and the first sonata for woodwind was this Flute and Piano Sonata composed in 1936 in Berlin. The first performance of Flute and Piano Sonata was performed by Georges Barrère and Jesus Maria Sanroma on April 10, 1937, during Hindemith's visit to the US that year, at the Library of Congress in Washington. Hindemith's Flute and Piano Sonata consists of three parts: Heiter bewegt, Sehr langsam, Sehr lebhaft and Marsch. Hindemith's Flute and Piano Sonata, which does not have a certain order in the relations between tones, is an example of neo-classicalism in terms of form and motif usage.