Fiziksel İnaktivite ve Sirkadiyen (Biyolojik) Ritim Bozukluklarının Obeziteye Etkisi
Abstract views: 31 / PDF downloads: 16
DOI:
https://doi.org/10.5281/zenodo.14257248Anahtar Kelimeler:
Fiziksel İnaktivite, Sirkadiyen Ritim, ObesiteÖzet
Bilinçli ve kaliteli bir yaşam sürdürebilmek için fiziksel inaktivitenin ve biyolojik ritmin bozulma nedenleri ile bu bozulmaların obeziteye etkilerinin bilinmesi önemlidir. Bu çalışma, fiziksel inaktivitenin ve sirkadiyen (biyolojik) ritim bozukluklarının obezite üzerindeki etkilerini incelemeyi amaçlamaktadır. Literatür araştırması için PubMed, Web of Science, Scopus ve Google Scholar gibi bilimsel veritabanlarında araştırmalar yapılmıştır. Fiziksel aktivite, genel sağlık ve refah için kritik bir faktördür, ancak günümüzde artan sedanter yaşam tarzı, obezite prevalansını artırmaktadır. Fiziksel inaktivite, uyku kalitesini düşürür ve bu da biyolojik ritmin bozulmasına yol açar. Biyolojik ritimlerdeki bozulmalar, obeziteye katkıda bulunan çeşitli fizyolojik değişikliklere neden olabilir. Düşük fiziksel aktivite seviyeleri, enerji dengesizliğine ve aşırı yağ birikimine yol açarak obezite riskini artırmaktadır. Araştırmalar, uykunun kısıtlanmasının, hipotalamusta bulunan merkezi biyolojik saatin sirkadiyen ritmini bozabileceğini ve bunun, uyku-uyanıklık döngülerini düzenleyen melatonin hormonu üzerinde olumsuz etkiler yarattığını göstermektedir. Alkol ve nikotin gibi maddelerin kullanımı da biyolojik ritimleri bozabilir. Özellikle gece boyunca yapay ışığa maruz kalmak, sirkadiyen ritimleri önemli ölçüde bozabilir. Ayrıca, kronik stres, sirkadiyen ritimlerin bozulmasına neden olarak kortizol seviyelerini artırabilir ve bu durum duygudurum bozukluklarına yol açabilir. Sirkadiyen ritim bozuklukları, glikoz regülasyonu ve yağ asidi oksidasyonunda rol oynayan adiponektin hormonunun düzenlenmesini bozarak yağ birikimini artırabilir. Uyku süresi ve kalitesi biyolojik ritimlerle yakından ilişkilidir; uyku bozuklukları ise obezite riskini artırabilir. Sosyal jetlag yaşayan bireyler, düzensiz uyku-uyanıklık döngüleri ve yeme alışkanlıkları nedeniyle kilo alabilir ve obezite riski artabilir. Sirkadiyen ritim bozuklukları, iştah ve enerji dengesini düzenleyen hormonal salgılarda değişikliklere yol açabilir. Özellikle kısa uyku süresi, artan ghrelin (açlık hormonu) seviyeleri ve azalan leptin (tokluk hormonu) salınımları, aşırı yemek yeme ve kilo alma döngüsünü başlatarak obeziteye yol açabilir. Sonuç olarak, fiziksel inaktivite enerji dengesizliğine ve aşırı yağ birikimine yol açarak obezite riskini artırdığı saptanmıştır. Sirkadiyen ritim bozukluklarının en önemli nedenlerinden birinin uyku düzensizliği olduğu ve metabolik düzensizliklere neden olarak iştahı ve enerji dengesini düzenleyen hormonalar da değişiklikler yaparak aşırı yemek yeme ve kilo alma sürecini tetikleyebildiği, dolayısıyla obeziteye neden olduğu saptanmıştır. Sağlık politikalarında, bireylerin fiziksel aktivite düzeylerini artırmaya yönelik teşvikler ve biyolojik ritimlerin korunmasına yönelik farkındalık çalışmalarına daha fazla yer verilmesi gerekmektedir.
Referanslar
Aguilar-Arnal, L. & Sassone–Corsi, P. (2014). Chromatin landscape and circadian dynamics: spatial and temporal organization of clock transcription. Proceedings of the national academy of sciences, 112(22), 6863-6870. https://doi.org/10.1073/pnas.1411264111
Ahmad, M., Din, N. S. B. M., Tharumalay, R. D., Din, N. C., Ibrahim, N., Amit, N., … & Ahmad, S. (2020). The effects of circadian rhythm disruption on mental health and physiological responses among shift workers and general population. International Journal of environmental research and public health, 17(19), 7156. https://doi.org/10.3390/ijerph17197156
Aktan, R. & Özalevli, S. (2017). Comparison of pulmonary functions, physical activity level and quality of life in obese and pre-obese individuals. Eurasian eournal of pulmonology, 19(3), 160-165. https://doi. org/10.5152/ejp.2017.18291
Anderson, P. (2008). Reducing overweight and obesity: closing the gap between primary care and public health. Family practice, 25(Supplement 1), 10-16. https://doi.org/10.1093/fampra/cmn060
Azboy, Y. (2021). Fiziksel aktivite ve sağlık. Sağlık ve yaşam bilimleri dergisi, 3(2), 140-144. https://doi. org/10.33308/2687248x.202132221
Bae, S. & Androulakis, I. P. (2018). Mathematical analysis of circadian disruption and metabolic re- entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding. American journal of physiology-endocrinology and metabolism, 314(6),531-542. https://doi.org/10.1152/ajpendo. 00271.2017
Biswas, M., Gibby, O. M., Ivanova-Stoilova, T., & Harding, K. (2010). Cushing's syndrome and chronic venous ulceration - a clinical challenge. International wound journal, 8(1), 99-102. https://doi.org/10.1111/j. 1742-481x.2010.00746.x
Buxton, O. M., Cain, S. W., O’Connor, S., Porter, J., Duffy, J. F., Wang, W., … & Shea, S. A. (2012). Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Science translational medicine, 4(129). https://doi.org/10.1126/scitranslmed.3003200
Büyükdere, Y. & Akyol, A. (2023). Diyetteki endokrin bozucular arasında bir obezojen: akrilamid. Journal of nutrition and dietetics. https://doi.org/10.33076/2023.bdd.1699
Cavanaugh, D., Urbanucci, A., Mohamed, N. E., Tewari, A. K., Figueiro, M., & Kyprianou, N. (2024). Link between circadian rhythm and benign prostatic hyperplasia (bph)/lower urinary tract symptoms (luts). The prostate, 84(5), 417-425. https://doi.org/10.1002/pros.24656
Cooper, A., Goodman, A., Page, A., Sherar, L., Esliger, D., Sluijs, E., … & Ekelund, U. (2015). Objectively measured physical activity and sedentary time in youth: the international children’s accelerometry database (icad). International journal of behavioral nutrition and physical activity, 12(1). https://doi.org/10. 1186/s12966-015-0274-5
Çakır, H. İ., Ersoy, A., & Çakır, G. (2022). Investigation of physical activity levels of middle school students and their parents in the covid-19 pandemic period. Spor eğitim dergisi, 6(1), 43-56. https://doi.org/10. 55238/seder.1039935
Dağlı, S. Ç. (2022). Bir belediyenin spor salonuna devam eden kadınlarda sağlıklı yaşam biçimi davranışları. Gaziantep ,üniversitesi spor Bilimleri dergisi, 7(2), 153-162. https://doi.org/10. 31680/gaunjss.1122742
Denis, G. V. & Obin, M. S. (2013). ‘metabolically healthy obesity’: origins and implications. Molecular aspects of medicine, 34(1), 59-70. https://doi.org/10.1016/j.mam.2012.10.004
Egesoy, H., Yapıcı, A., Sönmez, S., &Yüksel, Y. (2023). Acute effect of circadian rhythm on some performance parameters in young football players: relational study. Turkiye klinikleri journal of sports sciences, 15(2), 194-201. https://doi.org/10.5336/sportsci.2022-92995
Franco, M. R., Tong, A., Howard, K., Sherrington, C., Ferreira, P. H., Pinto, R. Z., … & Ferreira, M. L. (2015). Older people's perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature. British journal of sports medicine, 49(19), 1268-1276. https://doi.org/10. 1136/bjsports-2014-094015
Ginting, J. (2023). The association of age, gender, and physical inactivity with obesity. Jurnal prima medika sains, 5(2), 147-150. https://doi.org/10.34012/jpms.v5i2.4474
Gómez-Abellán, P., Gómez-Santos, C., Madrid, J. A., Milagro, F. I., Campión, J., Martínéz, J. A., … & Garaulet, M. (2010). Circadian expression of adiponectin and its receptors in human adipose tissue. Endocrinology, 151(1), 115-122. https://doi.org/10.1210/en.2009-0647
Greenway, F. L. (2015). Physiological adaptations to weight loss and factors favouring weight regain. International journal of obesity, 39(8), 1188-1196. https://doi.org/10.1038/ijo.2015.59
Hardiyanti, W. E. & Ilham, M. (2019). A qualitative study of teachers’ perceptions of children’s physical activity and learning in preschool. Al-Izzah: Jurnal hasil-hasil penelitian, 14(2), 141. https://doi.org/10. 31332/ai.v14i2.1524
Hargens, T. A., Kaleth, A. S., Edwards, E. S., & Butner, K. L. (2013). Association between sleep disorders, obesity, and exercise: a review. Nature and science of sleep, 27. https://doi.org/10.2147/nss.s34838
Hills, A. P., Andersen, L. B., & Byrne, N. M. (2011). Physical activity and obesity in children. British journal of sports medicine, 45(11), 866-870. https://doi.org/10.1136/bjsports-2011-090199
Honda Barros, S. S., Lopes, A. S., & Barros, M. V. G. (2012). Prevalência de baixo nível de atividade física em crianças pré-escolares. Revista brasileira de cineantropometria e desempenho humano, 14(4). https://doi.org/10.5007/1980-0037.2012v14n4p390
Hsieh, S. D., Muto, T., Murase, T., Tsuji, H., & Arase, Y. (2011). Association of short sleep duration with obesity, diabetes, fatty liver and behavioral factors in japanese men. Internal medicine, 50(21), 2499-2502. https://doi.org/10.2169/internalmedicine.50.5844
Janssen, I. & LeBlanc, A. G. (2010). Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. International journal of behavioral nutrition and physical activity, 7(1), 40. https://doi.org/10.1186/1479-5868-7-40
Kaar, J. L., Schmiege, S. J., Vadiveloo, M., Simon, S. L., & Tovar, A. (2018). Sleep duration mediates the relationship between health behavior patterns and obesity. Sleep health, 4(5), 442-447. https://doi.org/10. 1016/j.sleh.2018.07.004
Kazmi, T., Nagi, L., Iqbal, S., Razzak, S., Hassnain, S., Khan, S., … & Shahid, N. (2022). Relationship between physical inactivity and obesity in the urban slums of lahore. Cureus. 14(4). https://doi.org/10.7759/ cureus.23719
Krishnan, N., Rakshit, K., Chow, E. S., Wentzell, J. S., Kretzschmar, D., & Giebułtowicz, J. M. (2012). Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiology of disease, 45(3), 1129-1135. https://doi.org/10.1016/j.nbd.2011.12.034
Lee, I., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., & Katzmarzyk, P. T. (2012). Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. The lancet, 380(9838), 219-229. https://doi.org/10.1016/s0140-6736(12)61031-9
Li, W., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2022). Role of sleep restriction in daily rhythms of expression of hypothalamic core clock genes in mice. Current ıssues in molecular biology, 44(2), 609-625. https://doi.org/10.3390/cimb44020042
Lindwall, M., Gerber, M., Jonsdottir, I. H., Börjesson, M., & Ahlborg, G. (2014). The relationships of change in physical activity with change in depression, anxiety, and burnout: a longitudinal study of swedish healthcare workers. Health psychology, 33(11), 1309-1318. https://doi.org/10.1037/a 0034402
Martínez‐García, M. Á., Moncayo, S., Insenser, M., Álvarez‐Blasco, F., Luque‐Ramírez, M., & Escobar- Morreale, H. F. (2019). Metabolic cytokines at fasting and during macronutrient challenges: influence of obesity, female androgen excess and sex. Nutrients, 11(11), 2566. https://doi.org/10. 3390/nu11112566
Mason, K., Page, L., & Balikcioglu, P. G. (2014). Screening for hormonal, monogenic, and syndromic disorders in obese infants and children. Pediatric annals, 43(9). https://doi.org/10.3928/00904481- 20140825-08
Masri, S. & Sassone–Corsi, P. (2012). The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nature reviews neuroscience, 14(1), 69-75. https://doi.org/10.1038/nrn3393
Medina, C., Janssen, I., Campos‐Nonato, I., & Barquera, S. (2013). Physical inactivity prevalence and trends among mexican adults: results from the national health and nutrition survey (ensanut) 2006 and 2012. BMC Public health, 13(1). https://doi.org/10.1186/1471-2458-13-1063
Melo, M. C. A., Abreu, R. L. C., Neto, V. B. L., Bruin, P. F. C. d., & Bruin, V. M. S. d. (2017). Chronotype and circadian rhythm in bipolar disorder: a systematic review. Sleep medicine reviews, 34, 46-58. https://doi.org/10.1016/j.smrv.2016.06.007
Moran, M., Cauwenberg, J. V., Hercky-Linnewiel, R., Cerin, E., Deforche, B., & Plaut, P. O. (2014). Understanding the relationships between the physical environment and physical activity in older adults: a systematic review of qualitative studies. International journal of behavioral nutrition and physical activity, 11(1). https://doi.org/10.1186/1479-5868-11-79
Moreira, F. P., Jansen, K., Mondin, T. C., Cardoso, T. d. A., Magalhães, P. V. d. S., Kapczinski, F., … & Wiener, C. D. (2016). Biological rhythms, metabolic syndrome and current depressive episode in a community sample. Psychoneuroendocrinology, 72, 34-39. https://doi.org/10.1016/j.psyneuen.2016. 06.007
Oh, C. E., Lim, H., Park, J., Moon, E., &Park, J. K. (2022). Relationship of circadian rhythm in behavioral characteristics and lipid peroxidation of brain tissues in mice. Clinical psychopharmacology and neuroscience, 20(4), 649-661. https://doi.org/10.9758/cpn.2022.20.4.649
Parsons, M., Moffitt, T. E., Gregory, A. M., Goldman‐Mellor, S., Nolan, P. M., Poulton, R., … & Caspi, A. (2014). Social jetlag, obesity and metabolic disorder: investigation in a cohort study. International journal of obesity, 39(5), 842-848. https://doi.org/10.1038/ijo.2014.201
Pérez, S., Murias, L., Fernández-Plaza, C., Dı́az, I., González, C., Otero, J. M. G., … & Dı́az, E. (2015). Evidence for clock genes circadian rhythms in human full-term placenta. Systems biology in reproductive medicine, 61(6), 360-366. https://doi.org/10.3109/19396368.2015.1069420
Petrov, M. E., Wyst, K. B. V., Whisner, C. M., Jeong, M., Denniston, M., Moramarco, M. W., … & Reifsnider, E. (2017). Relationship of sleep duration and regularity with dietary intake among preschool-aged children with obesity from low-income families. Journal of developmental and amp; Behavioral pediatrics, 38(2), 120-128. https://doi.org/10.1097/dbp.0000000000000369
Piercy, K. L., Troiano, R. P., Ballard, R., Carlson, S. A., Fulton, J. E., Galuska, D. A., … & Olson, R. D. (2018). The physical activity guidelines for americans. Jama, 320(19), 2020. https://doi.org/10.1001/jama. 2018.14854
Rangul, V., Bauman, A., Holmen, T. L., & Midthjell, K. (2012). Is physical activity maintenance from adolescence to young adulthood associated with reduced cvd risk factors, improved mental health and satisfaction with life: the hunt study, norway. International journal of behavioral nutrition and physical activity, 9(1), 144. https://doi.org/10.1186/1479-5868-9-144
Rahelu, K. (2010). Is inactivity the cause of fatness or fatness the cause of inactivity?. Nutrition bulletin, 35(4), 304-307. https://doi.org/10.1111/j.1467-3010.2010.01854.x
Salavaty, A. (2015). Carcinogenic effects of circadian disruption: an epigenetic viewpoint. Chinese journal of Cancer, 34(3). https://doi.org/10.1186/s40880-015-0043-5
Samir, N., Mahmud, S., & Khuwaja, A. (2011). Prevalence of physical inactivity and barriers to physical activity among obese attendants at a community health-care center in karachi, pakistan. BMC Research notes, 4(1). https://doi.org/10.1186/1756-0500-4-174
Schippers, J. H. M., Lai, A. G., Mueller‐Roeber, B., & Dijkwel, P. P. (2013). Could ros signals drive tissue-specific clocks?. Transcription, 4(5), 206-208. https://doi.org/10.4161/trns.26362
Selvi, Y., Beşiroğlu, L., & Aydın, A. (2011). Chronobiology and mood disorders. Psikiyatride guncel yaklasimlar - current approaches in psychiatry, 368. https://doi.org/10.5455/cap.20110317
Shanmugam, V., Wafi, A. W., Al-Taweel, N., & Büsselberg, D. (2013). Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease. Journal of local and global health science, 2013(1). https://doi.org/10.5339/jlghs.2013.3
Škrlec, I., Talapko, J., Džijan, S., Cesar, V., Lazić, N., & Lepeduš, H. (2021). The association between circadian clock gene polymorphisms and metabolic syndrome: a systematic review and meta- analysis. Biology, 11(1), 20. https://doi.org/10.3390/biology11010020
Stevenson, T. J. (2018). Epigenetic regulation of biological rhythms: an evolutionary ancient molecular timer. Trends in genetics, 34(2), 90-100. https://doi.org/10.1016/j.tig.2017.11.003
Şahin, B., Bozkurt, A., & Karabekiroğlu, K. (2018). Sleep problems in children with attention deficit hyperactivity disorder. Düzce tıp fakültesi dergisi, 20(3), 81-86. https://doi.org/10.18678/dtfd. 489684
Takeda, N., Maemura, K., Horie, S., Oishi, K., Imai, Y., Harada, T., … & Nagai, R. (2007). Thrombomodulin is a clock-controlled gene in vascular endothelial cells. Journal of biological chemistry, 282(45), 32561-32567. https://doi.org/10.1074/jbc.m705692200
Tanaka, A., Mochizuki, T., Ishibashi, T., Akamizu, T., Matsuoka, T., & Nishi, M. (2022). Reduced fat taste sensitivity in obese japanese patients and its recovery after a short-term weight loss program. Journal of nutritional science and vitaminology, 68(6), 504-512. https://doi.org/10.3177/jnsv.68.504
Theorell‐Haglöw, J. & Lindberg, E. (2016). Sleep duration and obesity in adults: what are the connections?. Current obesity reports, 5(3), 333-343. https://doi.org/10.1007/s13679-016-0225-8
Tremblay, M. S., Kho, M. E., Tricco, A. C., & Duggan, M. (2010). Process description and evaluation of canadian physical activity guidelines development. International journal of behavioral nutrition and physical activity, 7(1), 42. https://doi.org/10.1186/1479-5868-7-42
Tremblay, M. S., LeBlanc, A. G., Carson, V., Choquette, L., Gorber, S. C., Dillman, C., … & Timmons, A. W. (2012). Canadian physical activity guidelines for the early years (aged 0–4 years). Applied physiology, nutrition, and metabolism, 37(2), 345-356. https://doi.org/10.1139/h2012-018
Tucker, J., Tucker, L., LeCheminant, J., & Bailey, B. (2013). Obesity increases risk of declining physical activity over time in women: a prospective cohort study. Obesity, 21(12). https://doi.org/10.1002/oby.20415
Vural, Ö., Eler, S., ve Güzel, N. A. (2010). Masa başi çalişanlarda fı̇zı̇ksel aktı̇vı̇te düzeyı̇ ve yaşam kalı̇tesı̇ ı̇lı̇şkı̇sı̇. Ankara üniversitesi beden eğitimi ve spor yüksekokulu, spormetre beden eğitimi ve spor bilimleri dergisi, 069-075. https://doi.org/10.1501/sporm_0000000178
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020). Circadian rhythm disruption and mental health. Translational psychiatry, 10(1). https://doi.org/10.1038/s41398-020-0694-0
Wang, J., Xie, Y., Xu, H., Wan, Y., & Tao, F. (2023). Moderating effects of smoking and drinking on the relationship between biological rhythm and psychological health and gender differences among adolescents. BMC Psychiatry, 23(1). https://doi.org/10.1186/s12888-023-05253-2
West, A. C. & Bechtold, D. A. (2015). The cost of circadian desynchrony: evidence, insights and open questions. BioEssays, 37(7), 777-788. https://doi.org/10.1002/bies.201400173
Westerterp-Plantenga, M. S. (2016). Sleep, circadian rhythm and body weight: parallel developments. Proceedings of the nutrition society, 75(4), 431-439. https://doi.org/10.1017/s0029665116000227
Ye, J., Gao, Z., Yin, J., & He, Q. (2007). Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue ofob/oband dietary obese mice. American journal of physiology-endocrinology and metabolism, 293(4), 1118-1128. https://doi.org/10.1152/ajpendo.00435.2007
Yilmaz, A. (2019). Üniversite öğrencilerinde fiziksel aktivite, sedanter süre ve yaşam kalitesi ı̇lişkisinin değerlendirilmesi. OPUS Uluslararası toplum araştırmaları dergisi. https://doi.org/10.26466/opus. 532283
Yuan, M., Qu, J., Hong, W., & Li, P. (2020). Reconciling periodic rhythms of large-scale biological networks by optimal control. Royal society open science, 7(1), 191698. https://doi.org/10. 1098/rsos.191698
Zhang, Y., Yang, J., Ye, J., Guo, Q., Wang, W., Sun, Y., … & Zeng, Q. (2019). Separate and combined associations of physical activity and obesity with lipid-related indices in non-diabetic and diabetic patients. Lipids in health and disease, 18(1). https://doi.org/10.1186/s12944-019-0987-6
Zhao, H., Lu, C., & Yi, C. (2023). Physical activity and sleep quality association in different populations: a meta-analysis. International journal of environmental research and public health, 20(3), 1864. https://doi.org/10.3390/ijerph20031864
Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British journal of pharmacology, 175(16), 3190-3199. https://doi.org/10.1111/bph.14116
İndir
Yayınlanmış
Nasıl Atıf Yapılır
Sayı
Bölüm
Lisans
Telif Hakkı (c) 2024 International Journal of Social and Humanities Sciences Research (JSHSR)
Bu çalışma Creative Commons Attribution 4.0 International License ile lisanslanmıştır.